We study and reprogram cellular systems through biomolecular engineering.
Our research focuses on developing and applying biomolecular tools to probe gene and protein function in mammalian systems and to advance therapeutic development. By integrating chemical biology, protein engineering, genome editing, and targeted delivery technologies, we aim to uncover fundamental regulatory mechanisms and translate them into new molecular interventions.
Protein Engineering & Directed Evolution
We develop directed evolution platforms in different cellular contexts to engineer proteins with enhanced activity, specificity, and stability. Our work focuses on building versatile protein scaffolds and regulatory elements that enable precise control of cellular processes for both basic research and therapeutic applications.
Genome Editing & RNA-Guided Enzymes
We engineer RNA-guided enzymes with improved precision, efficiency, and programmability for gene editing in mammalian cells. Our work focuses on developing next-generation genome and transcriptome editing strategies for human biology that enable therapeutic gene modulation and functional genomics.
Epigenetic Regulation & Functional Genomics
We repurpose and engineer nucleic acid-modifying enzymes for targeted epigenetic editing and gene regulation in mammalian systems. These tools enable systematic interrogation of chromatin states and transcriptional networks to elucidate regulatory mechanisms in complex biological contexts.
Targeted Delivery & Nanomedicines
We develop nanoparticle-based delivery platforms for the efficient and tissue-selective transport of therapeutic nucleic acids and proteins in vivo. Our work focuses on overcoming delivery barriers in genome editing and RNA-based therapies, with Rett syndrome and related genetic disorders serving as translational models.
